PSMB7

Across TCGA pan-cancer cohorts, PSMB7 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated PSMB7 data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher PSMB7 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PSMB7 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

LSCC, PDAC, and HNSC are the cancer types where PSMB7 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	II,III,IV	0.929	0.424	.002	21	view →
PDAC	DFS	Tertile	III,IV	0.305	0.865	.005	9	view →
HNSC	DFS	Median	IV	0.328	0.889	.014	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

PSMB7–LSCC (OS)

Open the LSCC breakdown →