PSMB4

Across TCGA pan-cancer cohorts, PSMB4 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PSMB4 data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher PSMB4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PSMB4 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

COAD, CCRCC, and HNSC are the cancer types where PSMB4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.913	1.000	.007	36	view →
CCRCC	DFS	Quartile	All	0.949	0.589	.002	24	view →
HNSC	DFS	Tertile	III,IV	1.000	0.885	.013	12	view →
LSCC	DFS	Median	All	1.000	0.597	.006	9	view →
LUAD	DFS	Median	III,IV	0.690	0.305	.032	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PSMB4–COAD (DFS)

Open the COAD breakdown →