PSMB4

Across TCGA patient cohorts, PSMB4 mutation is significantly associated with the RNA expression of many other genes, with 698 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSMB4-associated genes across cancer lineages are LINC02488, RNU6-1199P, and RNA5SP518. Each is linked with PSMB4 in more than 2 cancer types. Because this analysis shows association rather than direction, both PSMB4-to-partner and partner-to-PSMB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02488 grouped by PSMB4-low versus PSMB4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMB4→partner) and Y-score (partner→PSMB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	LINC02488 →	+0.292	+5.037	<.001	.009	3	3
BRCA	RNU6-1199P →	+0.354	+5.175	.007	.007	3	2
LUSC	RNA5SP518 →	+0.358	+7.924	<.001	.008	3	2
SKCM	RNU6-454P →	+0.355	+5.594	<.001	.004	3	2
SKCM	RNU6ATAC29P →	+0.364	+6.080	<.001	.002	3	2
UCEC	RPL34P36 →	+0.081	+2.953	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 698 associations by consensus.

LINC02488 by PSMB4 expression — SKCM

Explore this box plot interactively →