PSMB4

Across TCGA cell cohorts, PSMB4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,245 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible PSMB4-associated GO terms across cancer lineages are Threonyl-tRNA aminoacylation, Regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, and Lung development. Each is linked with PSMB4 in more than 10 cancer types. Because this analysis shows association rather than direction, both PSMB4-to-partner and partner-to-PSMB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Threonyl-tRNA aminoacylation grouped by PSMB4-low versus PSMB4-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMB4→partner) and Y-score (partner→PSMB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Threonyl-tRNA aminoacylation →	+0.162	+0.834	<.001	<.001	3	11
BREAST	Regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction →	-0.052	-0.788	.002	<.001	3	10
SKIN	Lung development →	-0.096	-0.578	<.001	.006	3	9
BLOOD_Lymphoma	Respiratory system development →	-0.100	-0.459	.002	<.001	3	9
LUNG_NSCLC_LUSC	Regulation of lysosome size →	+0.093	+0.553	.004	.002	2	10
BLOOD_Myeloma	Protein transmembrane transport →	+0.066	+0.746	.001	.008	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,245 associations by consensus.

Threonyl-tRNA aminoacylation by PSMB4 expression — BONE

Explore this box plot interactively →