PSMB3

Across TCGA pan-cancer cohorts, PSMB3 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PSMB3 data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher PSMB3 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PSMB3 expression acts as an unfavorable survival marker, although some lineages such as PDAC and UCEC show a favorable association.

PDAC, LSCC, and UCEC are the cancer types where PSMB3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	All	0.473	0.270	.001	20	view →
LSCC	OS	Median	II,III,IV	0.584	0.870	.009	7	view →
UCEC	DFS	Quartile	All	0.969	0.783	.031	6	view →
LUAD	OS	Median	II,III,IV	0.339	0.906	.004	6	view →
HNSC	OS	Median	III,IV	1.000	0.946	.037	3	view →
CCRCC	DFS	Median	III,IV	1.000	0.451	.032	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PSMB3–PDAC (OS)

Open the PDAC breakdown →