PSMB3

Across TCGA pan-cancer cohorts, PSMB3 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of PSMB3’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where PSMB3 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types PSMB3 is over-expressed in tumor, although a few such as PDAC show the opposite, repressed pattern.

CCRCC, PDAC, and OV are the cancer types where PSMB3 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PSMB3 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	All	+0.170	.005	7	view →
PDAC	Female	II,III,IV	−0.376	.005	3	view →
OV	All	All	+0.451	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

PSMB3–CCRCC

Open the CCRCC breakdown →