PSMB3

Across TCGA patient cohorts, PSMB3 mutation is significantly associated with the RNA expression of many other genes, with 76 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSMB3-associated genes across cancer lineages are RNA5SP86, SMG1P4, and RNU6-222P. Each is linked with PSMB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSMB3-to-partner and partner-to-PSMB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP86 grouped by PSMB3-low versus PSMB3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMB3→partner) and Y-score (partner→PSMB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP86 →	+0.660	+3.299	<.001	.006	3	2
UCEC	SMG1P4 →	+0.163	+3.728	<.001	.004	3	1
UCEC	RNU6-222P →	+0.792	+2.902	<.001	.006	3	1
UCEC	RNY1P16 →	+0.711	+2.976	<.001	.003	3	1
UCEC	RNU4-13P →	+0.168	+4.242	<.001	.006	3	1
UCEC	RNU6-879P →	+0.468	+2.903	.008	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 76 associations by consensus.

RNA5SP86 by PSMB3 expression — UCEC

Explore this box plot interactively →