PSMB3

Across TCGA patient cohorts, PSMB3 mutation is significantly associated with the immune_cell of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSMB3-associated genes across cancer lineages are CD8+ Tem, NK cells, and mv Endothelial cells. Each is linked with PSMB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSMB3-to-partner and partner-to-PSMB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD8+ Tem grouped by PSMB3-low versus PSMB3-high in ESCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMB3→partner) and Y-score (partner→PSMB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	CD8+ Tem →	+0.018	+5.285	<.001	.049	3	1
ESCA	NK cells →	+0.002	+5.709	.002	.037	3	1
UCEC	mv Endothelial cells →	-0.031	-2.989	.025	.037	3	1
UCEC	lymphatic Endothelial cells →	-0.029	-2.959	.033	.036	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

CD8+ Tem by PSMB3 expression — ESCA

Explore this box plot interactively →