PSMB2

Across TCGA pan-cancer cohorts, PSMB2 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PSMB2 data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PSMB2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PSMB2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

LUAD, HNSC, and CCRCC are the cancer types where PSMB2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.434	0.905	<.001	33	view →
HNSC	OS	Tertile	II,III,IV	1.000	0.936	.020	11	view →
CCRCC	DFS	Median	II,III,IV	1.000	0.514	.022	10	view →
UCEC	OS	Median	III,IV	1.000	0.494	.016	8	view →
PDAC	OS	Quartile	II,III,IV	0.506	0.277	.019	5	view →
LSCC	DFS	Tertile	All	1.000	0.529	.030	4	view →
GBM	DFS	Quartile	All	0.628	0.837	.031	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PSMB2–LUAD (DFS)

Open the LUAD breakdown →