Across TCGA patient cohorts, PSMB11 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSMB11-associated genes across cancer lineages are p62 Lck ligand, TFRC, and EGFR_pY1068. Each is linked with PSMB11 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSMB11-to-partner and partner-to-PSMB11 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMB11→partner) and Y-score (partner→PSMB11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.532	+3.594	<.001	.001	3	2
UCEC	TFRC →	+0.610	+2.115	.008	.019	3	2
UCEC	EGFR_pY1068 →	-0.294	-3.700	.007	.001	3	1
UCEC	A-Raf_pS299 →	-0.173	-3.459	<.001	.005	3	1
UCEC	FOXO3a_pS318_S321 →	-0.145	-1.990	.007	.030	3	1
UCEC	ACVRL1 →	-0.145	-3.308	.015	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Exploration

PSMB11 survival (RNA) · tumor vs normal (RNA) · all PSMB11 data types