Across TCGA pan-cancer cohorts, PSMB10 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated PSMB10 data layer compared with 25 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher PSMB10 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PSMB10 expression acts as an unfavorable survival marker.

COAD, SKCM, and HNSC are the cancer types where PSMB10 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.163	0.802	<.001	48	view →
SKCM	DFS	Median	All	0.147	0.730	<.001	16	view →
HNSC	DFS	Median	II,III,IV	0.170	0.662	.016	9	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: PSMB10 tumor-vs-normal RNA expression · all PSMB10 data types