PSMB1

Across TCGA pan-cancer cohorts, PSMB1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PSMB1 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher PSMB1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PSMB1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

COAD, CCRCC, and LSCC are the cancer types where PSMB1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.916	1.000	.010	36	view →
CCRCC	DFS	Tertile	All	0.955	0.734	.011	15	view →
LSCC	DFS	Tertile	All	1.000	0.395	.008	9	view →
LUAD	DFS	Median	III,IV	0.977	0.504	.005	8	view →
HNSC	OS	Median	All	0.991	0.943	.031	5	view →
GBM	OS	Quartile	All	0.941	0.814	.009	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PSMB1–COAD (DFS)

Open the COAD breakdown →