PSMB1

Across TCGA patient cohorts, PSMB1 mutation is significantly associated with the RNA expression of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSMB1-associated genes across cancer lineages are RN7SKP132, VN1R84P, and ARHGAP42P4. Each is linked with PSMB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSMB1-to-partner and partner-to-PSMB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP132 grouped by PSMB1-low versus PSMB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSMB1→partner) and Y-score (partner→PSMB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SKP132 →	+0.176	+4.292	<.001	.006	3	2
UCEC	VN1R84P →	+0.777	+3.411	.002	.007	3	1
SKCM	ARHGAP42P4 →	+0.015	+5.680	<.001	.003	3	1
SKCM	AIDAP3 →	+0.157	+5.867	<.001	.003	3	1
BLCA	NCSTNP1 →	+0.343	+7.640	<.001	.009	3	1
BLCA	C4B-AS1 →	+0.029	+7.640	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

RN7SKP132 by PSMB1 expression — UCEC

Explore this box plot interactively →