PSMA7

Across TCGA pan-cancer cohorts, PSMA7 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated PSMA7 data layer compared with 2 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher PSMA7 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PSMA7 expression acts as an unfavorable survival marker, although some lineages such as COAD and READ show a favorable association.

UVM, HNSC, and LIHC are the cancer types where PSMA7 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	II,III,IV	0.318	0.795	<.001	104	view →
HNSC	DFS	Quartile	All	0.633	0.803	<.001	99	view →
LIHC	OS	Median	All	0.598	0.768	<.001	78	view →
MESO	OS	Tertile	All	0.365	0.668	<.001	77	view →
ACC	OS	Median	All	0.771	0.965	<.001	73	view →
BLCA	OS	Median	II,III,IV	0.654	0.785	.002	68	view →
LGG	DFS	Median	All	0.650	0.822	<.001	52	view →
KICH	DFS	Quartile	All	0.673	1.000	.013	39	view →
BRCA	OS	Tertile	II,III,IV	0.585	0.657	.001	36	view →
LAML	DFS	Quartile	All	0.375	0.661	.002	36	view →
KIRP	OS	Tertile	All	0.492	0.881	.003	35	view →
COAD	OS	Median	IV	0.576	0.310	.006	25	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

PSMA7–UVM (DFS)

Open the UVM breakdown →