PSMA6

Across TCGA pan-cancer cohorts, PSMA6 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PSMA6 data layer compared with 22 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher PSMA6 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PSMA6 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LSCC show a favorable association.

COAD, LUAD, and UCEC are the cancer types where PSMA6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.917	1.000	.010	72	view →
LUAD	OS	Tertile	All	0.665	0.914	.007	15	view →
UCEC	OS	Median	All	1.000	0.910	.013	8	view →
OV	DFS	Median	All	0.711	1.000	.048	4	view →
LSCC	DFS	Tertile	All	0.877	0.397	.024	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PSMA6–COAD (DFS)

Open the COAD breakdown →