PSMA5

Across TCGA pan-cancer cohorts, PSMA5 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PSMA5 data layer compared with 23 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher PSMA5 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PSMA5 expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

COAD, LSCC, and PDAC are the cancer types where PSMA5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Quartile	II,III,IV	0.867	1.000	.010	36	view →
LSCC	DFS	Tertile	All	0.944	0.255	<.001	11	view →
PDAC	DFS	Quartile	II,III,IV	0.478	0.299	.016	11	view →
CCRCC	DFS	Quartile	II,III,IV	0.904	0.066	.024	8	view →
UCEC	DFS	Median	All	0.954	0.857	.030	8	view →
GBM	DFS	Tertile	All	0.236	0.426	.010	6	view →
HNSC	DFS	Tertile	III,IV	1.000	0.905	.021	5	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PSMA5–COAD (DFS)

Open the COAD breakdown →