Across TCGA pan-cancer cohorts, PSMA2P3 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of PSMA2P3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PSMA2P3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PSMA2P3 is over-expressed in tumor, although a few such as PAAD and LUSC show the opposite, repressed pattern.

HNSC, COAD, and LUAD are the cancer types where PSMA2P3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PSMA2P3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+0.057	.008	6	view →
COAD	All	All	+0.287	<.001	5	view →
LUAD	All	II,III,IV	+0.120	.011	3	view →
PAAD	Male	All	−0.140	.005	2	view →
LUSC	Male	III,IV	−0.120	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: PSMA2P3 RNA expression & survival · all PSMA2P3 data types