PSKH2

Across TCGA patient cohorts, PSKH2 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSKH2-associated genes across cancer lineages are EGFR_pY1068, TFRC, and Cyclin-B1. Each is linked with PSKH2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSKH2-to-partner and partner-to-PSKH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by PSKH2-low versus PSKH2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSKH2→partner) and Y-score (partner→PSKH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.244	-2.807	.026	.003	3	2
UCEC	TFRC →	+0.606	+2.999	.008	.035	3	2
UCEC	Cyclin-B1 →	+0.617	+2.115	.011	.019	3	2
UCEC	JNK_pT183_Y185 →	-0.182	-2.999	.013	.035	3	1
UCEC	p38-MAPK →	-0.156	-2.986	.029	.035	3	1
UCEC	p62 Lck ligand →	+0.502	+2.331	<.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

EGFR_pY1068 by PSKH2 expression — UCEC

Explore this box plot interactively →