PSKH1

Across TCGA patient cohorts, PSKH1 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSKH1-associated genes across cancer lineages are MSH2, Shc_pY317, and TFRC. Each is linked with PSKH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSKH1-to-partner and partner-to-PSKH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by PSKH1-low versus PSKH1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSKH1→partner) and Y-score (partner→PSKH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.324	-2.321	<.001	.006	3	2
UCEC	Shc_pY317 →	-0.172	-1.807	.005	.027	3	2
UCEC	TFRC →	+0.520	+2.321	.017	.006	3	2
UCEC	c-Met_pY1235 →	+0.068	+1.874	.025	.049	3	2
UCEC	4E-BP1 →	+0.258	+2.199	.021	.033	3	2
UCEC	eIF4E →	+0.208	+2.321	.016	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

MSH2 by PSKH1 expression — UCEC

Explore this box plot interactively →