PSIP1

Across TCGA pan-cancer cohorts, PSIP1 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated PSIP1 data layer compared with 22 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PSIP1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PSIP1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and CCRCC show a favorable association.

UCEC, LUAD, and CCRCC are the cancer types where PSIP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	III,IV	0.424	1.000	.003	30	view →
LUAD	DFS	Tertile	All	0.773	0.449	.002	21	view →
CCRCC	OS	Median	III,IV	0.857	0.533	.011	11	view →
LSCC	OS	Quartile	II,III,IV	0.998	0.782	.017	8	view →
HNSC	DFS	Quartile	All	0.685	0.871	.034	5	view →
OV	DFS	Median	All	0.831	1.000	.012	4	view →
PDAC	DFS	Quartile	All	0.750	0.601	.030	3	view →
GBM	OS	Tertile	All	0.524	0.249	.016	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

PSIP1–UCEC (DFS)

Open the UCEC breakdown →