PSIP1

Across TCGA patient cohorts, PSIP1 mutation is significantly associated with the RNA expression of many other genes, with 2,832 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSIP1-associated genes across cancer lineages are RNA5SP88, RNA5SP198, and RNA5SP139. Each is linked with PSIP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PSIP1-to-partner and partner-to-PSIP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP88 grouped by PSIP1-low versus PSIP1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSIP1→partner) and Y-score (partner→PSIP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNA5SP88 →	+0.310	+5.081	<.001	.004	3	3
CESC	RNA5SP198 →	+0.277	+5.144	<.001	.003	3	3
LUSC	RNA5SP139 →	+0.707	+4.503	<.001	.005	3	3
UCEC	INO80B-WBP1 →	+0.092	+1.758	<.001	.002	3	2
HNSC	OR7A15P →	+0.061	+3.478	.002	.008	3	2
HNSC	HLFP1 →	+0.051	+4.339	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,832 associations by consensus.

RNA5SP88 by PSIP1 expression — LUSC

Explore this box plot interactively →