PSIP1

Across TCGA patient cohorts, PSIP1 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSIP1-associated genes across cancer lineages are Annexin_VII, Shc_pY317, and ATM. Each is linked with PSIP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PSIP1-to-partner and partner-to-PSIP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin_VII grouped by PSIP1-low versus PSIP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSIP1→partner) and Y-score (partner→PSIP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin_VII →	-0.129	-1.847	.011	.008	3	2
UCEC	Shc_pY317 →	-0.191	-1.847	<.001	.008	3	2
UCEC	ATM →	-0.599	-3.700	<.001	.001	2	3
UCEC	C-Raf →	+0.207	+2.321	<.001	.005	3	2
BLCA	PRAS40_pT246 →	+0.179	+3.459	.002	.005	3	1
BLCA	Smac →	+0.309	+2.858	.004	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Annexin_VII by PSIP1 expression — UCEC

Explore this box plot interactively →