PSG6

Across TCGA cell cohorts, PSG6 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PSG6-associated genes across cancer lineages are TECRL, C3orf85, and XKR7. Each is linked with PSG6 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSG6-to-partner and partner-to-PSG6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TECRL grouped by PSG6-low versus PSG6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSG6→partner) and Y-score (partner→PSG6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TECRL →	+0.012	+3.562	<.001	.002	3	2
BLOOD_Leukemia	C3orf85 →	+0.026	+4.124	<.001	<.001	3	1
BLOOD_Leukemia	XKR7 →	+0.201	+3.495	.001	.005	3	1
LUNG_NSCLC_LUAD	COX4I2 →	+0.054	+4.228	<.001	<.001	3	1
LUNG_NSCLC_LUAD	C1orf189 →	+0.264	+3.717	<.001	.005	3	1
LUNG_NSCLC_LUAD	CCL18 →	+0.022	+3.628	.004	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

TECRL by PSG6 expression — LARGE_INTESTINE

Explore this box plot interactively →