PSG5

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, PSG5 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSG5-associated genes across cancer lineages are MYH11, Rad50, and Chk1. Each is linked with PSG5 in more than 2 cancer types. Because this analysis shows association rather than direction, both PSG5-to-partner and partner-to-PSG5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSG5→partner) and Y-score (partner→PSG5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
SKCMMYH11 →-0.592-1.115.018.02433
UCECRad50 →-0.290-2.700.007.00632
LUADChk1 →+0.251+3.000.043.03632
UCECGAPDH →+0.700+2.700.003.00632
UCECNotch1 →+0.173+2.331.006.01932
UCECp38-MAPK_pT180_Y182 →-0.545-3.794.007<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

Exploration