PSG4

Across TCGA patient cohorts, PSG4 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSG4-associated genes across cancer lineages are p38-MAPK_pT180_Y182, ASNS, and PCNA. Each is linked with PSG4 in more than 2 cancer types. Because this analysis shows association rather than direction, both PSG4-to-partner and partner-to-PSG4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by PSG4-low versus PSG4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSG4→partner) and Y-score (partner→PSG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.360	-3.459	.042	.005	3	3
UCEC	ASNS →	+0.316	+2.459	.026	.019	3	3
COAD	PCNA →	+0.345	+3.008	.007	.019	3	2
UCEC	eEF2 →	+0.472	+3.321	<.001	.009	3	2
UCEC	GAPDH →	+0.447	+2.321	.034	.034	3	2
UCEC	IGFBP2 →	-0.771	-3.169	.002	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

p38-MAPK_pT180_Y182 by PSG4 expression — UCEC

Explore this box plot interactively →