Across TCGA patient cohorts, PSG3 mutation is significantly associated with the RNA expression of many other genes, with 1,583 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSG3-associated genes across cancer lineages are NR2C2AP, THOP1, and SGTA. Each is linked with PSG3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PSG3-to-partner and partner-to-PSG3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSG3→partner) and Y-score (partner→PSG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	NR2C2AP →	+0.418	+2.632	.007	.005	3	3
LUAD	THOP1 →	+0.510	+3.735	.002	<.001	3	3
UCEC	SGTA →	+0.503	+4.005	<.001	<.001	3	3
UCEC	GFER →	+0.342	+1.936	.004	.003	3	3
UCEC	SIRT6 →	+0.408	+2.961	<.001	<.001	3	3
COAD	AGPAT5P1 →	+0.061	+4.721	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,583 associations by consensus.

Exploration

PSG3 survival (RNA) · tumor vs normal (RNA) · all PSG3 data types