PSG2

Across TCGA patient cohorts, PSG2 mutation is significantly associated with the RNA expression of many other genes, with 3,813 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSG2-associated genes across cancer lineages are CHAF1B, RECQL4, and TEDC2. Each is linked with PSG2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PSG2-to-partner and partner-to-PSG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHAF1B grouped by PSG2-low versus PSG2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSG2→partner) and Y-score (partner→PSG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CHAF1B →	+0.585	+2.137	<.001	.001	3	3
UCEC	RECQL4 →	+0.539	+3.700	.005	.001	3	3
UCEC	TEDC2 →	+0.533	+2.831	.001	.001	3	3
UCEC	CCNF →	+0.516	+2.914	.004	.001	3	3
UCEC	STOML2 →	+0.430	+2.137	.001	.001	3	3
UCEC	NOLC1 →	+0.485	+3.721	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,813 associations by consensus.

CHAF1B by PSG2 expression — UCEC

Explore this box plot interactively →