PSG10P

Across TCGA patient cohorts, PSG10P mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSG10P-associated genes across cancer lineages are 4E-BP1, Mre11, and Tuberin. Each is linked with PSG10P in more than 1 cancer types. Because this analysis shows association rather than direction, both PSG10P-to-partner and partner-to-PSG10P results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by PSG10P-low versus PSG10P-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSG10P→partner) and Y-score (partner→PSG10P) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	4E-BP1 →	+0.241	+2.321	.027	.001	3	2
UCEC	Mre11 →	-0.098	-2.584	.014	.011	2	2
UCEC	Tuberin →	+0.299	+2.179	.017	.034	3	1
UCEC	Caspase-8 →	-0.272	-3.584	.020	.002	2	2
UCEC	Dvl3 →	+0.194	+2.584	.023	.011	3	1
SKCM	AMPK_alpha →	+0.123	+1.584	.014	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

4E-BP1 by PSG10P expression — SKCM

Explore this box plot interactively →