PSG1

Across TCGA patient cohorts, PSG1 mutation is significantly associated with the RNA expression of many other genes, with 4,600 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSG1-associated genes across cancer lineages are TIMM44, NDUFC1, and TTK. Each is linked with PSG1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PSG1-to-partner and partner-to-PSG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIMM44 grouped by PSG1-low versus PSG1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSG1→partner) and Y-score (partner→PSG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIMM44 →	+0.456	+1.839	<.001	<.001	3	3
UCEC	NDUFC1 →	+0.339	+2.072	<.001	<.001	3	3
SKCM	TTK →	+0.454	+1.613	.001	<.001	3	3
UCEC	TARS1 →	+0.439	+1.378	.001	.008	3	3
UCEC	CENPA →	+0.495	+2.186	.008	.001	3	3
SKCM	STMN1 →	+0.438	+1.555	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,600 associations by consensus.

TIMM44 by PSG1 expression — UCEC

Explore this box plot interactively →