PSG1

Across TCGA patient cohorts, PSG1 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSG1-associated genes across cancer lineages are A-Raf_pS299, Annexin-1, and Snail. Each is linked with PSG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSG1-to-partner and partner-to-PSG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by PSG1-low versus PSG1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSG1→partner) and Y-score (partner→PSG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.136	-1.584	<.001	.017	3	2
UCEC	Annexin-1 →	+0.521	+2.700	.001	.005	3	2
UCEC	Snail →	-0.223	-3.169	.029	<.001	3	2
UCEC	VEGFR2 →	+0.361	+2.906	<.001	.001	3	2
UCEC	Cyclin-B1 →	+0.558	+1.523	.001	.008	3	2
SKCM	Heregulin →	+0.120	+1.302	.011	.012	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

A-Raf_pS299 by PSG1 expression — UCEC

Explore this box plot interactively →