PSG1

Across TCGA cell cohorts, PSG1 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PSG1-associated genes across cancer lineages are OR10A5, RXFP2, and OR6C70. Each is linked with PSG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSG1-to-partner and partner-to-PSG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10A5 grouped by PSG1-low versus PSG1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSG1→partner) and Y-score (partner→PSG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	OR10A5 →	+0.036	+4.029	<.001	.009	3	1
LUNG_NSCLC_LUAD	RXFP2 →	+0.051	+3.544	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR6C70 →	+0.292	+4.681	<.001	.003	3	1
LUNG_NSCLC_LUAD	LILRA5 →	+0.030	+4.189	<.001	.002	3	1
LARGE_INTESTINE	GALR3 →	+0.084	+3.602	.004	.005	3	1
LARGE_INTESTINE	SIGLECL1 →	+0.011	+2.977	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

OR10A5 by PSG1 expression — OVARY

Explore this box plot interactively →