PSD3

Across TCGA pan-cancer cohorts, PSD3 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of PSD3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PSD3 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types PSD3 is over-expressed in tumor, although a few such as HNSC and CCRCC show the opposite, repressed pattern.

HNSC, CCRCC, and COAD are the cancer types where PSD3 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PSD3 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	−0.318	<.001	8	view →
CCRCC	Male	III,IV	−0.453	<.001	6	view →
COAD	Male	All	−0.639	<.001	5	view →
LSCC	All	All	+0.120	.004	3	view →
OV	All	All	−0.510	.030	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

PSD3–HNSC

Open the HNSC breakdown →