PSD3

Across TCGA patient cohorts, PSD3 mutation is significantly associated with the RNA expression of many other genes, with 6,727 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSD3-associated genes across cancer lineages are FAM136A, DNA2, and RN7SL134P. Each is linked with PSD3 in more than 4 cancer types. Because this analysis shows association rather than direction, both PSD3-to-partner and partner-to-PSD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM136A grouped by PSD3-low versus PSD3-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSD3→partner) and Y-score (partner→PSD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	FAM136A →	+0.527	+3.219	.004	.009	3	5
UCEC	DNA2 →	+0.484	+2.081	<.001	<.001	3	4
LUAD	RN7SL134P →	+0.113	+3.415	<.001	.002	3	4
UCEC	HMGXB4 →	+0.485	+1.673	<.001	<.001	3	3
UCEC	E2F1 →	+0.861	+2.010	<.001	<.001	3	3
UCEC	CST3 →	-0.510	-1.652	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,727 associations by consensus.

FAM136A by PSD3 expression — STAD

Explore this box plot interactively →