PSD3

Across TCGA patient cohorts, PSD3 mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSD3-associated genes across cancer lineages are Ku80, TFRC, and ATM. Each is linked with PSD3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PSD3-to-partner and partner-to-PSD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by PSD3-low versus PSD3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSD3→partner) and Y-score (partner→PSD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.155	+1.235	.020	.007	3	3
UCEC	TFRC →	+0.509	+1.584	<.001	.001	3	3
UCEC	ATM →	-0.382	-1.440	.003	.022	3	3
UCEC	Cyclin-B1 →	+0.756	+2.237	<.001	<.001	3	3
BLCA	MYH11 →	-1.049	-3.321	.019	.010	3	2
UCEC	14-3-3_beta →	-0.087	-1.899	.002	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

Ku80 by PSD3 expression — UCEC

Explore this box plot interactively →