PSD2

Across TCGA patient cohorts, PSD2 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSD2-associated genes across cancer lineages are FASN, ACC1, and STAT3_pY705. Each is linked with PSD2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PSD2-to-partner and partner-to-PSD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by PSD2-low versus PSD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSD2→partner) and Y-score (partner→PSD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.237	+1.362	.049	.034	3	3
UCEC	ACC1 →	+0.238	+1.263	.032	.019	3	3
UCEC	STAT3_pY705 →	-0.231	-1.311	.003	.027	3	3
UCEC	eIF4E →	+0.170	+2.713	.008	.003	3	2
UCEC	JNK2 →	+0.166	+1.834	.006	.013	3	2
UCEC	Notch1 →	+0.105	+1.335	.014	.041	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

FASN by PSD2 expression — UCEC

Explore this box plot interactively →