PSD2

Across TCGA cell cohorts, PSD2 mutation is significantly associated with the RNA expression of many other genes, with 251 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PSD2-associated genes across cancer lineages are SLC2A7, GALP, and L3MBTL2. Each is linked with PSD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSD2-to-partner and partner-to-PSD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC2A7 grouped by PSD2-low versus PSD2-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSD2→partner) and Y-score (partner→PSD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SLC2A7 →	+0.016	+4.906	<.001	.006	3	1
SKIN	GALP →	+0.022	+5.415	<.001	.004	3	1
LARGE_INTESTINE	L3MBTL2 →	+0.645	+3.169	<.001	.006	3	1
LARGE_INTESTINE	USP14 →	+0.572	+2.451	.009	.009	3	1
LARGE_INTESTINE	CUEDC2 →	+0.655	+3.386	<.001	.001	3	1
LARGE_INTESTINE	MYH3 →	+0.702	+3.234	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 251 associations by consensus.

SLC2A7 by PSD2 expression — OESOPHAGUS

Explore this box plot interactively →