PSD2

Across TCGA cell cohorts, PSD2 mutation is significantly associated with the mutation status of many other genes, with 5,382 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PSD2-associated genes across cancer lineages are TRAK2, MYOM2, and VNN1. Each is linked with PSD2 in more than 3 cancer types. Because this analysis shows association rather than direction, both PSD2-to-partner and partner-to-PSD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAK2 grouped by PSD2-low versus PSD2-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSD2→partner) and Y-score (partner→PSD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	TRAK2 →	+5.000	+5.000	.006	.006	1	4
KIDNEY	MYOM2 →	+5.000	+5.000	.006	.006	1	4
LUNG_NSCLC_LUAD	VNN1 →	+5.924	+5.924	<.001	<.001	1	4
LUNG_NSCLC_LUAD	GSE1 →	+2.754	+4.189	.008	.008	1	4
BLOOD_Leukemia	NPAS3 →	+4.145	+4.635	.001	.001	1	4
BLOOD_Leukemia	RET →	+4.560	+4.309	.007	.007	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,382 associations by consensus.

TRAK2 by PSD2 expression — KIDNEY

Explore this box plot interactively →