PSD

Across TCGA pan-cancer cohorts, PSD Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PSD data layer compared with 24 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PSD Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated PSD expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, STAD, and LUAD are the cancer types where PSD Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.982	0.889	.010	28	view →
STAD	OS	Median	II,III,IV	0.199	0.710	.003	9	view →
LUAD	OS	Median	III,IV	0.223	0.677	.006	9	view →
SKCM	OS	Median	IV	0.415	0.861	.014	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PSD–UCEC (DFS)

Open the UCEC breakdown →