PSD

Across TCGA patient cohorts, PSD mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSD-associated genes across cancer lineages are VHL, eIF4E, and JNK2. Each is linked with PSD in more than 1 cancer types. Because this analysis shows association rather than direction, both PSD-to-partner and partner-to-PSD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by PSD-low versus PSD-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSD→partner) and Y-score (partner→PSD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	VHL →	-0.515	-2.000	.045	.029	3	2
UCEC	eIF4E →	+0.237	+2.222	<.001	<.001	3	2
UCEC	JNK2 →	+0.141	+1.348	.020	.040	3	2
UCEC	p62 Lck ligand →	+0.253	+1.700	.011	.001	3	2
UCEC	PCNA →	+0.259	+2.222	<.001	<.001	3	2
UCEC	PDCD4 →	-0.551	-3.906	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

VHL by PSD expression — SKCM

Explore this box plot interactively →