PSD

Across TCGA cell cohorts, PSD mutation is significantly associated with the RNA expression of many other genes, with 950 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PSD-associated genes across cancer lineages are GPR63, CPO, and GLOD4. Each is linked with PSD in more than 1 cancer types. Because this analysis shows association rather than direction, both PSD-to-partner and partner-to-PSD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR63 grouped by PSD-low versus PSD-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSD→partner) and Y-score (partner→PSD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GPR63 →	+0.912	+2.700	<.001	.001	3	2
LARGE_INTESTINE	CPO →	+0.077	+2.415	.004	.004	3	2
LARGE_INTESTINE	GLOD4 →	+0.660	+3.321	<.001	.002	3	2
LARGE_INTESTINE	KSR2 →	+0.420	+2.158	<.001	.004	3	2
URINARY_TRACT	OPN1MW2 →	+0.020	+5.087	<.001	.004	3	1
BREAST	RGS21 →	+0.005	+4.781	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 950 associations by consensus.

GPR63 by PSD expression — LARGE_INTESTINE

Explore this box plot interactively →