PSAT1

Across TCGA patient cohorts, PSAT1 mutation is significantly associated with the RNA expression of many other genes, with 923 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSAT1-associated genes across cancer lineages are RN7SKP286, CDY3P, and RNA5SP417. Each is linked with PSAT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSAT1-to-partner and partner-to-PSAT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP286 grouped by PSAT1-low versus PSAT1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSAT1→partner) and Y-score (partner→PSAT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RN7SKP286 →	+0.047	+4.810	<.001	.002	3	2
SKCM	CDY3P →	+0.008	+3.993	<.001	.008	3	2
UCEC	RNA5SP417 →	+0.543	+2.029	<.001	.007	3	2
UCEC	PPIAP75 →	-0.300	-3.172	<.001	<.001	3	1
UCEC	CYFIP1 →	+0.610	+3.023	<.001	<.001	3	1
UCEC	TAF9 →	+0.507	+2.584	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 923 associations by consensus.

RN7SKP286 by PSAT1 expression — SKCM

Explore this box plot interactively →