PSAT1

Across TCGA patient cohorts, PSAT1 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSAT1-associated genes across cancer lineages are Heregulin, MSH2, and MSH6. Each is linked with PSAT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSAT1-to-partner and partner-to-PSAT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heregulin grouped by PSAT1-low versus PSAT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSAT1→partner) and Y-score (partner→PSAT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Heregulin →	-0.121	-2.986	.025	.035	3	1
UCEC	MSH2 →	-0.346	-2.558	<.001	.010	3	1
UCEC	MSH6 →	-0.511	-2.999	<.001	.035	3	1
UCEC	Myosin-IIa →	+0.164	+1.592	.042	.044	3	1
UCEC	p90 RSK →	+0.170	+1.598	.042	.044	3	1
UCEC	PDK1_pS241 →	+0.165	+3.169	.026	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Heregulin by PSAT1 expression — UCEC

Explore this box plot interactively →