PSAPL1

Across TCGA patient cohorts, PSAPL1 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSAPL1-associated genes across cancer lineages are ACVRL1, JNK_pT183_Y185, and JNK2. Each is linked with PSAPL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSAPL1-to-partner and partner-to-PSAPL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACVRL1 grouped by PSAPL1-low versus PSAPL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSAPL1→partner) and Y-score (partner→PSAPL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACVRL1 →	-0.178	-3.446	.001	.005	3	2
UCEC	JNK_pT183_Y185 →	-0.251	-3.074	<.001	<.001	3	2
UCEC	JNK2 →	+0.298	+2.415	<.001	.003	3	2
UCEC	Bak →	+0.239	+2.000	.017	.029	3	2
UCEC	c-Kit →	-0.244	-2.565	.009	.010	3	2
UCEC	14-3-3_beta →	-0.101	-2.432	.012	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

ACVRL1 by PSAPL1 expression — UCEC

Explore this box plot interactively →