PSAPL1

Across TCGA cell cohorts, PSAPL1 mutation is significantly associated with the RNA expression of many other genes, with 306 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PSAPL1-associated genes across cancer lineages are HSCB, CNIH1, and CCDC113. Each is linked with PSAPL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PSAPL1-to-partner and partner-to-PSAPL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSCB grouped by PSAPL1-low versus PSAPL1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSAPL1→partner) and Y-score (partner→PSAPL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HSCB →	+0.582	+3.169	.003	.009	3	1
LARGE_INTESTINE	CNIH1 →	+0.548	+3.451	<.001	.002	3	1
LARGE_INTESTINE	CCDC113 →	+0.768	+3.451	.006	.002	3	1
LARGE_INTESTINE	SHOC2 →	+0.415	+3.364	.004	.002	3	1
LARGE_INTESTINE	NDUFC1 →	+0.688	+3.364	.001	.002	3	1
LARGE_INTESTINE	TTK →	+0.540	+3.064	.009	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 306 associations by consensus.

HSCB by PSAPL1 expression — LARGE_INTESTINE

Explore this box plot interactively →