Across TCGA pan-cancer cohorts, PSAP mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PSAP data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher PSAP mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PSAP expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

COAD, CCRCC, and LSCC are the cancer types where PSAP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	All	0.831	1.000	.013	78	view →
CCRCC	OS	Median	All	0.745	0.941	<.001	50	view →
LSCC	OS	Median	II,III,IV	1.000	0.883	.018	9	view →
PDAC	DFS	Median	All	0.741	0.782	.036	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: PSAP tumor-vs-normal RNA expression · all PSAP data types