PSAP

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, PSAP mutation is significantly associated with the RNA expression of many other genes, with 2,864 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PSAP-associated genes across cancer lineages are RNU6-1183P, MAP3K4-AS1, and PPP2R5E. Each is linked with PSAP in more than 1 cancer types. Because this analysis shows association rather than direction, both PSAP-to-partner and partner-to-PSAP results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSAP→partner) and Y-score (partner→PSAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BLCARNU6-1183P →+0.627+5.497.001.00432
UCECMAP3K4-AS1 →+0.717+1.745<.001.00432
UCECPPP2R5E →+0.402+2.431.004.00132
UCECSUPV3L1 →+0.419+3.711<.001<.00132
UCECTIGD3 →+0.469+2.201.002<.00132
UCECZNF654 →+0.515+2.917.001<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 2,864 associations by consensus.

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