Across TCGA cell cohorts, PSAP mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PSAP-associated genes across cancer lineages are ST8SIA2, CLDN8, and CRYAA. Each is linked with PSAP in more than 1 cancer types. Because this analysis shows association rather than direction, both PSAP-to-partner and partner-to-PSAP results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PSAP→partner) and Y-score (partner→PSAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ST8SIA2 →	+0.718	+3.504	<.001	.004	3	1
BLOOD_Leukemia	CLDN8 →	+0.008	+2.971	<.001	.003	3	1
BLOOD_Leukemia	CRYAA →	+0.058	+3.121	<.001	.003	3	1
BLOOD_Leukemia	LRRC38 →	+1.872	+4.116	<.001	<.001	3	1
BLOOD_Leukemia	INSM2 →	+0.121	+3.354	.005	.001	3	1
BLOOD_Leukemia	SNTG2 →	+1.205	+3.491	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Exploration

PSAP survival (RNA) · tumor vs normal (RNA) · all PSAP data types