PRUNE2

Across TCGA patient cohorts, PRUNE2 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,037 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible PRUNE2-associated proteins across cancer lineages are PRUNE2_S1842, PRUNE2_S699, and PRUNE2_S918. Each is linked with PRUNE2 in more than 9 cancer types. Because this analysis shows association rather than direction, both PRUNE2-to-partner and partner-to-PRUNE2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PRUNE2 versus PRUNE2_S1842 in HNSC, with a Pearson correlation of 0.78.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PRUNE2→partner) and Y-score (partner→PRUNE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PRUNE2_S1842 →	+1.239	+1.908	<.001	<.001	3	10
BRCA	PRUNE2_S699 →	+1.939	+1.761	.001	<.001	3	9
LUAD	PRUNE2_S918 →	+1.500	+1.704	<.001	<.001	3	7
LUAD	PRUNE2_S1788 →	+1.274	+1.509	<.001	<.001	3	7
BRCA	ASPA →	+0.803	+0.585	<.001	.001	3	6
UCEC	PRKCA →	+0.612	+1.050	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,037 associations by consensus.

PRUNE2 vs PRUNE2_S1842 — HNSC

Explore this scatter interactively →