PRUNE2

Across TCGA patient cohorts, PRUNE2 mutation is significantly associated with the total protein of many other genes, with 106 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRUNE2-associated genes across cancer lineages are Caveolin-1, Caspase-7-cleavedD198, and 4E-BP1. Each is linked with PRUNE2 in more than 4 cancer types. Because this analysis shows association rather than direction, both PRUNE2-to-partner and partner-to-PRUNE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caveolin-1 grouped by PRUNE2-low versus PRUNE2-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRUNE2→partner) and Y-score (partner→PRUNE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	Caveolin-1 →	-0.886	-3.321	.004	.009	3	5
COAD	Caspase-7-cleavedD198 →	+1.074	+1.815	<.001	.016	3	5
COAD	4E-BP1 →	+0.282	+2.700	<.001	.005	3	4
LUSC	Acetyl-a-Tubulin-Lys40 →	+0.571	+3.000	.007	.033	3	4
BRCA	Annexin_VII →	-0.160	-2.454	.016	.021	3	3
BRCA	C-Raf →	+0.164	+3.328	.011	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 106 associations by consensus.

Caveolin-1 by PRUNE2 expression — HNSC

Explore this box plot interactively →