PRUNE2

Across TCGA cell cohorts, PRUNE2 mutation is significantly associated with the RNA expression of many other genes, with 690 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRUNE2-associated genes across cancer lineages are PLD6, SSX2IP, and CMTM5. Each is linked with PRUNE2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRUNE2-to-partner and partner-to-PRUNE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLD6 grouped by PRUNE2-low versus PRUNE2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRUNE2→partner) and Y-score (partner→PRUNE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PLD6 →	+1.077	+3.395	.007	.002	3	3
LARGE_INTESTINE	SSX2IP →	+0.726	+2.222	.003	.001	3	3
BLOOD_Myeloma	CMTM5 →	+0.103	+3.285	<.001	.009	3	2
SOFT_TISSUE	AMY1C →	+0.020	+4.635	<.001	.003	3	2
OESOPHAGUS	RD3 →	+0.017	+2.906	.002	.004	3	2
LARGE_INTESTINE	MAPK8 →	+0.572	+2.459	.003	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 690 associations by consensus.

PLD6 by PRUNE2 expression — BLOOD_Lymphoma

Explore this box plot interactively →